PCGF5

Across TCGA cell cohorts, PCGF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,066 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCGF5-associated GO terms across cancer lineages are Nerve growth factor signaling pathway, Positive regulation of mitochondrial ATP synthesis coupled electron transport, and Regulation of protection from non-homologous end joining at telomere. Each is linked with PCGF5 in more than 10 cancer types. Because this analysis shows association rather than direction, both PCGF5-to-partner and partner-to-PCGF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nerve growth factor signaling pathway grouped by PCGF5-low versus PCGF5-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF5→partner) and Y-score (partner→PCGF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Nerve growth factor signaling pathway →	+0.160	+0.917	.003	.005	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.122	+1.118	<.001	<.001	3	8
LARGE_INTESTINE	Regulation of protection from non-homologous end joining at telomere →	-0.130	-0.835	.001	.004	3	7
LARGE_INTESTINE	Negative regulation of protection from non-homologous end joining at telomere →	-0.130	-0.835	.001	.004	3	7
BONE	Positive regulation of protein binding →	+0.136	+0.841	<.001	.001	3	7
LARGE_INTESTINE	Telomeric DNA-containing double minutes formation →	-0.130	-0.835	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,066 associations by consensus.

Nerve growth factor signaling pathway by PCGF5 expression — LIVER

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