PCGF5

Across TCGA cell cohorts, PCGF5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCGF5-associated genes across cancer lineages are C6orf118, DEFA4, and OR6Q1. Each is linked with PCGF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF5-to-partner and partner-to-PCGF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by PCGF5-low versus PCGF5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF5→partner) and Y-score (partner→PCGF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.192	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	RXFP2 →	+0.065	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	TXNDC8 →	+0.007	+5.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C6orf118 by PCGF5 expression — LARGE_INTESTINE

Explore this box plot interactively →