Across TCGA patient cohorts, PCGF3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCGF3-associated genes across cancer lineages are HER3_pY1289, eIF4E, and MEK1. Each is linked with PCGF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF3-to-partner and partner-to-PCGF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF3→partner) and Y-score (partner→PCGF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.074	+1.689	.014	.007	3	2
UCEC	eIF4E →	+0.174	+2.713	.019	.003	3	1
UCEC	MEK1 →	+0.371	+2.502	.004	.001	3	1
UCEC	MSH2 →	-0.264	-2.295	.001	.033	3	1
UCEC	Notch1 →	+0.124	+2.128	.013	.009	3	1
UCEC	PDCD4 →	-0.420	-1.874	.011	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PCGF3 survival (RNA) · tumor vs normal (RNA) · all PCGF3 data types