PCGF1

Across TCGA cell cohorts, PCGF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,965 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PCGF1-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Negative regulation of monocyte chemotactic protein-1 production, and Regulation of collagen fibril organization. Each is linked with PCGF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PCGF1-to-partner and partner-to-PCGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by PCGF1-low versus PCGF1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF1→partner) and Y-score (partner→PCGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.095	+0.530	.005	.005	3	8
BREAST	Negative regulation of monocyte chemotactic protein-1 production →	-0.171	-0.446	.001	.001	3	7
SKIN	Regulation of collagen fibril organization →	-0.196	-0.442	<.001	.001	3	7
URINARY_TRACT	Cardiac muscle contraction →	-0.105	-0.609	.004	.001	3	7
KIDNEY	Regulation of toll-like receptor signaling pathway →	+0.076	+0.390	.002	.009	3	7
SOFT_TISSUE	Cellular senescence →	+0.076	+0.894	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,965 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by PCGF1 expression — SOFT_TISSUE

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