PCF11

Across TCGA pan-cancer cohorts, PCF11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PCF11 data layer compared with 30 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PCF11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PCF11 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where PCF11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	1.000	0.367	.016	12	view →
HNSC	DFS	Median	All	0.698	1.000	.020	11	view →
GBM	OS	Quartile	All	0.617	0.252	<.001	7	view →
LUAD	DFS	Quartile	All	0.990	0.837	.032	5	view →
LSCC	DFS	Median	All	0.984	0.898	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PCF11–CCRCC (DFS)

Open the CCRCC breakdown →