PCED1B

Across TCGA patient cohorts, PCED1B mutation is significantly associated with the RNA expression of many other genes, with 1,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCED1B-associated genes across cancer lineages are SNRPD3, MLX, and GOT1. Each is linked with PCED1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PCED1B-to-partner and partner-to-PCED1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD3 grouped by PCED1B-low versus PCED1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCED1B→partner) and Y-score (partner→PCED1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPD3 →	+0.311	+2.000	.005	.003	3	3
UCEC	MLX →	+0.393	+3.048	.003	<.001	3	3
UCEC	GOT1 →	+0.350	+2.064	.008	.001	3	3
SKCM	PSMC3IP →	+0.501	+1.745	<.001	<.001	3	3
SKCM	UBL4A →	+0.260	+2.286	.005	<.001	3	3
SKCM	RFC5 →	+0.311	+1.938	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,600 associations by consensus.

SNRPD3 by PCED1B expression — UCEC

Explore this box plot interactively →