PCED1B

Across TCGA patient cohorts, PCED1B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCED1B-associated genes across cancer lineages are FASN, Cyclin-B1, and ACC1. Each is linked with PCED1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PCED1B-to-partner and partner-to-PCED1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PCED1B-low versus PCED1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCED1B→partner) and Y-score (partner→PCED1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.387	+1.925	.006	.005	3	3
UCEC	Cyclin-B1 →	+0.562	+2.584	.005	.010	3	3
UCEC	ACC1 →	+0.282	+1.700	.031	.042	3	2
SKCM	MYH11 →	-1.002	-4.000	<.001	<.001	3	2
SKCM	STAT3_pY705 →	-0.254	-1.906	.007	.014	3	2
UCEC	TFRC →	+0.582	+3.321	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FASN by PCED1B expression — UCEC

Explore this box plot interactively →