PCDHGC5

Across TCGA patient cohorts, PCDHGC5 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGC5-associated genes across cancer lineages are p53, PCNA, and MIG-6. Each is linked with PCDHGC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGC5-to-partner and partner-to-PCDHGC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by PCDHGC5-low versus PCDHGC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC5→partner) and Y-score (partner→PCDHGC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p53 →	-0.300	-2.450	.033	.020	3	1
COAD	PCNA →	+0.270	+3.182	.012	.009	3	1
SKCM	MIG-6 →	+0.152	+2.832	.046	.034	3	1
SKCM	PRAS40_pT246 →	-0.166	-2.459	.029	.020	3	1
UCEC	14-3-3_beta →	-0.072	-2.295	.045	.033	3	1
UCEC	EGFR_pY1068 →	-0.186	-2.000	.039	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p53 by PCDHGC5 expression — COAD

Explore this box plot interactively →