PCDHGC5

Across TCGA cell cohorts, PCDHGC5 mutation is significantly associated with the mutation status of many other genes, with 6,424 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGC5-associated genes across cancer lineages are ITPR3, PCDHA13, and PCDH8. Each is linked with PCDHGC5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGC5-to-partner and partner-to-PCDHGC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITPR3 grouped by PCDHGC5-low versus PCDHGC5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC5→partner) and Y-score (partner→PCDHGC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITPR3 →	+2.285	+3.520	.001	.001	1	5
BLOOD_Leukemia	PCDHA13 →	+2.243	+2.959	.008	.008	1	4
SKIN	PCDH8 →	+4.824	+5.392	.004	.004	1	4
LARGE_INTESTINE	HIVEP1 →	+2.155	+3.392	<.001	<.001	1	4
BLOOD_Leukemia	PPL →	+2.672	+3.866	<.001	<.001	1	4
LARGE_INTESTINE	CC2D1A →	+4.614	+4.614	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,424 associations by consensus.

ITPR3 by PCDHGC5 expression — BLOOD_Leukemia

Explore this box plot interactively →