PCDHGC4

Across TCGA cell cohorts, PCDHGC4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PCDHGC4-associated genes across cancer lineages are ASB17, C12orf40, and ZP4. Each is linked with PCDHGC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGC4-to-partner and partner-to-PCDHGC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by PCDHGC4-low versus PCDHGC4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC4→partner) and Y-score (partner→PCDHGC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
BLOOD_Lymphoma	ZP4 →	+0.297	+3.321	.006	.006	3	1
BLOOD_Lymphoma	LCE3D →	+0.144	+3.321	.002	.006	3	1
BLOOD_Lymphoma	PFN3 →	+0.043	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	KRTAP3-3 →	+0.030	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASB17 by PCDHGC4 expression — OVARY

Explore this box plot interactively →