PCDHGC3

Across TCGA patient cohorts, PCDHGC3 mutation is significantly associated with the RNA expression of many other genes, with 804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGC3-associated genes across cancer lineages are HSPD1P18, TCERG1L-AS1, and MIR596. Each is linked with PCDHGC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGC3-to-partner and partner-to-PCDHGC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPD1P18 grouped by PCDHGC3-low versus PCDHGC3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC3→partner) and Y-score (partner→PCDHGC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HSPD1P18 →	+0.199	+5.241	<.001	.007	3	3
UCEC	TCERG1L-AS1 →	+0.147	+1.589	.008	.005	3	3
LIHC	MIR596 →	+0.427	+5.355	<.001	.005	3	2
BLCA	MIR548U →	+0.312	+4.492	<.001	.005	3	2
UCEC	MIR4445 →	+0.118	+3.834	<.001	.007	3	2
UCEC	TAF9 →	+0.425	+2.136	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 804 associations by consensus.

HSPD1P18 by PCDHGC3 expression — HNSC

Explore this box plot interactively →