PCDHGC3

Across TCGA patient cohorts, PCDHGC3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGC3-associated genes across cancer lineages are XBP1, Fibronectin, and MSH6. Each is linked with PCDHGC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGC3-to-partner and partner-to-PCDHGC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by PCDHGC3-low versus PCDHGC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC3→partner) and Y-score (partner→PCDHGC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.125	-2.321	.024	.034	3	2
UCEC	Fibronectin →	-0.274	-1.990	.034	.030	3	1
UCEC	MSH6 →	-0.417	-1.584	.001	.036	3	1
UCEC	Akt_pT308 →	+0.547	+2.321	.027	.033	3	1
UCEC	PDK1_pS241 →	+0.162	+2.700	.015	.006	3	1
UCEC	PDK1 →	+0.086	+2.472	.042	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

XBP1 by PCDHGC3 expression — UCEC

Explore this box plot interactively →