PCDHGC3

Across TCGA cell cohorts, PCDHGC3 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGC3-associated genes across cancer lineages are OR4N4, C12orf57, and NQO2. Each is linked with PCDHGC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGC3-to-partner and partner-to-PCDHGC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by PCDHGC3-low versus PCDHGC3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC3→partner) and Y-score (partner→PCDHGC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4N4 →	+0.067	+3.643	.003	.007	3	2
LARGE_INTESTINE	C12orf57 →	+0.911	+3.252	<.001	.002	3	2
LARGE_INTESTINE	NQO2 →	+0.911	+2.743	.001	.001	3	2
LARGE_INTESTINE	C9orf72 →	+0.764	+2.743	<.001	.001	3	2
LARGE_INTESTINE	KCNJ11 →	+0.622	+3.169	.005	.006	3	2
LARGE_INTESTINE	EIF4B →	+0.574	+2.743	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

OR4N4 by PCDHGC3 expression — CNS

Explore this box plot interactively →