PCDHGB5

Across TCGA patient cohorts, PCDHGB5 mutation is significantly associated with the RNA expression of many other genes, with 2,523 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGB5-associated genes across cancer lineages are CENPM, WRAP53, and CDCA2. Each is linked with PCDHGB5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGB5-to-partner and partner-to-PCDHGB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by PCDHGB5-low versus PCDHGB5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB5→partner) and Y-score (partner→PCDHGB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPM →	+0.682	+3.584	.005	.002	3	5
COAD	WRAP53 →	+0.497	+3.652	<.001	.001	3	5
COAD	CDCA2 →	+0.687	+3.598	.004	.001	3	4
STAD	NDUFA12 →	+0.485	+3.509	<.001	.002	3	4
COAD	MRPL37 →	+0.384	+3.200	.004	.009	3	4
COAD	PIMREG →	+0.771	+3.183	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,523 associations by consensus.

CENPM by PCDHGB5 expression — COAD

Explore this box plot interactively →