PCDHGB5

Across TCGA patient cohorts, PCDHGB5 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGB5-associated genes across cancer lineages are Cyclin-B1, PCNA, and INPP4B. Each is linked with PCDHGB5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGB5-to-partner and partner-to-PCDHGB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PCDHGB5-low versus PCDHGB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB5→partner) and Y-score (partner→PCDHGB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.592	+2.807	.002	.003	3	4
STAD	PCNA →	+0.327	+3.169	.021	.019	2	4
UCEC	INPP4B →	-0.358	-3.807	.001	<.001	3	3
COAD	JNK_pT183_Y185 →	-0.234	-2.982	.046	.034	3	3
LUAD	P-Cadherin →	+0.261	+3.000	.002	.034	3	2
UCEC	EGFR_pY1068 →	-0.193	-1.736	.026	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Cyclin-B1 by PCDHGB5 expression — UCEC

Explore this box plot interactively →