PCDHGB3

Across TCGA patient cohorts, PCDHGB3 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGB3-associated genes across cancer lineages are EGFR_pY1068, ATM, and Caspase-7-cleavedD198. Each is linked with PCDHGB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGB3-to-partner and partner-to-PCDHGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PCDHGB3-low versus PCDHGB3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB3→partner) and Y-score (partner→PCDHGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.352	-2.700	.001	.005	3	4
UCEC	ATM →	-0.548	-2.209	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.595	+2.070	<.001	.001	3	4
BLCA	SF2 →	+0.281	+3.321	.001	.010	3	3
STAD	FoxM1 →	+0.319	+3.031	.009	.017	3	3
COAD	c-Kit →	-0.693	-2.807	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

EGFR_pY1068 by PCDHGB3 expression — COAD

Explore this box plot interactively →