PCDHGB3

Across TCGA cell cohorts, PCDHGB3 mutation is significantly associated with the RNA expression of many other genes, with 1,399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGB3-associated genes across cancer lineages are RTP5, HMGXB4, and PPP4R3A. Each is linked with PCDHGB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGB3-to-partner and partner-to-PCDHGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP5 grouped by PCDHGB3-low versus PCDHGB3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB3→partner) and Y-score (partner→PCDHGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RTP5 →	+0.731	+3.318	.003	.007	3	2
LARGE_INTESTINE	HMGXB4 →	+0.550	+2.265	<.001	.001	3	2
LARGE_INTESTINE	PPP4R3A →	+0.424	+2.351	.002	.001	3	2
LARGE_INTESTINE	PPP2R5D →	+0.635	+3.386	<.001	.001	3	2
LARGE_INTESTINE	PLCD4 →	+0.347	+2.459	.005	.006	3	2
LARGE_INTESTINE	SRSF4 →	+0.526	+2.949	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,399 associations by consensus.

RTP5 by PCDHGB3 expression — BLOOD_Leukemia

Explore this box plot interactively →