PCDHGB2

Across TCGA cell cohorts, PCDHGB2 mutation is significantly associated with the RNA expression of many other genes, with 593 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGB2-associated genes across cancer lineages are XRCC6, GPR101, and OR10G6. Each is linked with PCDHGB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGB2-to-partner and partner-to-PCDHGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XRCC6 grouped by PCDHGB2-low versus PCDHGB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB2→partner) and Y-score (partner→PCDHGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	XRCC6 →	+0.520	+2.628	.003	.002	3	2
STOMACH	GPR101 →	+0.013	+5.285	<.001	.003	3	1
STOMACH	OR10G6 →	+0.036	+5.285	<.001	.003	3	1
SKIN	CHRNB3 →	+0.007	+3.297	<.001	.002	3	1
BLOOD_Leukemia	CST8 →	+0.052	+4.969	<.001	.003	3	1
BLOOD_Leukemia	C9orf92 →	+0.081	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 593 associations by consensus.

XRCC6 by PCDHGB2 expression — LARGE_INTESTINE

Explore this box plot interactively →