PCDHGA9

Across TCGA patient cohorts, PCDHGA9 mutation is significantly associated with the RNA expression of many other genes, with 2,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA9-associated genes across cancer lineages are GNPDA1, LRR1, and MIR4695. Each is linked with PCDHGA9 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGA9-to-partner and partner-to-PCDHGA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPDA1 grouped by PCDHGA9-low versus PCDHGA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA9→partner) and Y-score (partner→PCDHGA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPDA1 →	+0.474	+3.000	<.001	<.001	3	4
UCEC	LRR1 →	+0.549	+2.523	<.001	<.001	3	4
CESC	MIR4695 →	+0.246	+4.516	<.001	.004	3	3
UCEC	CDKN3 →	+0.827	+3.010	<.001	<.001	3	3
UCEC	CPQ →	-0.664	-2.576	<.001	.001	3	3
LUAD	PLAT →	-1.219	-3.075	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,790 associations by consensus.

GNPDA1 by PCDHGA9 expression — UCEC

Explore this box plot interactively →