PCDHGA9

Across TCGA cell cohorts, PCDHGA9 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PCDHGA9-associated genes across cancer lineages are OR52E8, RSPH6A, and INHBC. Each is linked with PCDHGA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA9-to-partner and partner-to-PCDHGA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E8 grouped by PCDHGA9-low versus PCDHGA9-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA9→partner) and Y-score (partner→PCDHGA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR52E8 →	+0.017	+3.944	<.001	.006	3	2
LARGE_INTESTINE	RSPH6A →	+0.107	+3.688	.001	.001	3	1
LARGE_INTESTINE	INHBC →	+0.217	+3.389	.004	.007	3	1
LARGE_INTESTINE	FAM153B →	+0.392	+3.841	.002	<.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.018	+3.009	<.001	.001	3	1
OVARY	ASCL3 →	+0.144	+3.459	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

OR52E8 by PCDHGA9 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →