PCDHGA8

Across TCGA patient cohorts, PCDHGA8 mutation is significantly associated with the RNA expression of many other genes, with 5,442 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA8-associated genes across cancer lineages are TYMS, HSPA14, and NUF2. Each is linked with PCDHGA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA8-to-partner and partner-to-PCDHGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by PCDHGA8-low versus PCDHGA8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA8→partner) and Y-score (partner→PCDHGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TYMS →	+0.795	+4.087	<.001	<.001	3	5
UCEC	HSPA14 →	+0.399	+1.550	<.001	<.001	3	5
UCEC	NUF2 →	+0.427	+1.160	.009	.004	3	5
UCEC	NDUFA6 →	+0.501	+1.702	<.001	<.001	3	4
COAD	CENPM →	+0.656	+1.917	<.001	.009	3	4
UCEC	PRMT5 →	+0.470	+1.885	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,442 associations by consensus.

TYMS by PCDHGA8 expression — COAD

Explore this box plot interactively →