PCDHGA8

Across TCGA patient cohorts, PCDHGA8 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA8-associated genes across cancer lineages are PCNA, STAT3_pY705, and PDCD4. Each is linked with PCDHGA8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGA8-to-partner and partner-to-PCDHGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PCDHGA8-low versus PCDHGA8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA8→partner) and Y-score (partner→PCDHGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PCNA →	+0.341	+2.594	<.001	.006	3	4
LUAD	STAT3_pY705 →	-0.424	-3.000	.001	.035	3	3
UCEC	PDCD4 →	-0.488	-2.070	<.001	.001	3	3
UCEC	TFRC →	+0.589	+1.494	<.001	.001	3	3
UCEC	c-Met_pY1235 →	+0.045	+1.000	.027	.033	3	3
UCEC	4E-BP1 →	+0.351	+3.392	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

PCNA by PCDHGA8 expression — LUSC

Explore this box plot interactively →