PCDHGA8

Across TCGA cell cohorts, PCDHGA8 mutation is significantly associated with the RNA expression of many other genes, with 724 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA8-associated genes across cancer lineages are COL1A1, TIFA, and ACTR6. Each is linked with PCDHGA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA8-to-partner and partner-to-PCDHGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL1A1 grouped by PCDHGA8-low versus PCDHGA8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA8→partner) and Y-score (partner→PCDHGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COL1A1 →	+1.241	+3.366	<.001	.002	3	2
BLOOD_Leukemia	TIFA →	+1.158	+3.351	.004	.003	3	2
LARGE_INTESTINE	ACTR6 →	+0.591	+3.299	.005	.004	3	2
LARGE_INTESTINE	PIMREG →	+1.025	+3.212	<.001	.006	3	2
LARGE_INTESTINE	MAP3K10 →	+0.780	+3.067	.001	.009	3	2
LARGE_INTESTINE	FAM124A →	+0.975	+3.304	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 724 associations by consensus.

COL1A1 by PCDHGA8 expression — BLOOD_Leukemia

Explore this box plot interactively →