PCDHGA8

Across TCGA cell cohorts, PCDHGA8 mutation is significantly associated with the mutation status of many other genes, with 3,273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA8-associated genes across cancer lineages are ZMYM3, CACNA1G, and FTMT. Each is linked with PCDHGA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA8-to-partner and partner-to-PCDHGA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMYM3 grouped by PCDHGA8-low versus PCDHGA8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA8→partner) and Y-score (partner→PCDHGA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZMYM3 →	+3.285	+3.133	<.001	<.001	1	5
SOFT_TISSUE	CACNA1G →	+3.777	+3.307	.005	.005	1	5
BLOOD_Leukemia	FTMT →	+4.545	+3.020	.004	.004	1	5
LARGE_INTESTINE	DYSF →	+1.621	+2.280	.003	.003	1	5
BREAST	IMPG2 →	+4.297	+4.857	.009	.009	1	4
LUNG_NSCLC_LUAD	PCDHGA3 →	+3.478	+3.303	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,273 associations by consensus.

ZMYM3 by PCDHGA8 expression — SKIN

Explore this box plot interactively →