PCDHGA6

Across TCGA patient cohorts, PCDHGA6 mutation is significantly associated with the RNA expression of many other genes, with 7,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA6-associated genes across cancer lineages are FBXO7, CSTF2, and OARD1. Each is linked with PCDHGA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA6-to-partner and partner-to-PCDHGA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO7 grouped by PCDHGA6-low versus PCDHGA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA6→partner) and Y-score (partner→PCDHGA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO7 →	+0.445	+2.423	<.001	<.001	3	5
UCEC	CSTF2 →	+0.384	+2.513	<.001	<.001	3	5
LUAD	OARD1 →	+0.437	+2.924	<.001	<.001	3	5
STAD	TOM1L1 →	+0.800	+2.824	<.001	.001	3	5
SKCM	FAM177A1 →	+0.343	+1.783	.004	.001	3	5
UCEC	SLC7A6OS →	+0.507	+2.202	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,290 associations by consensus.

FBXO7 by PCDHGA6 expression — UCEC

Explore this box plot interactively →