PCDHGA6

Across TCGA patient cohorts, PCDHGA6 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA6-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and FoxM1. Each is linked with PCDHGA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGA6-to-partner and partner-to-PCDHGA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PCDHGA6-low versus PCDHGA6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA6→partner) and Y-score (partner→PCDHGA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.775	+2.016	.002	.015	3	4
UCEC	ATM →	-0.429	-1.432	.001	.005	3	4
LUAD	FoxM1 →	+0.293	+2.472	.008	.010	3	3
UCEC	Shc_pY317 →	-0.149	-1.857	<.001	<.001	3	3
COAD	ASNS →	+0.389	+2.222	.002	.009	3	3
UCEC	C-Raf →	+0.137	+1.440	.001	.022	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Caspase-7-cleavedD198 by PCDHGA6 expression — COAD

Explore this box plot interactively →