PCDHGA6

Across TCGA cell cohorts, PCDHGA6 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA6-associated genes across cancer lineages are OR2B2, CD300H, and PPDPFL. Each is linked with PCDHGA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA6-to-partner and partner-to-PCDHGA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B2 grouped by PCDHGA6-low versus PCDHGA6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA6→partner) and Y-score (partner→PCDHGA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2B2 →	+0.065	+4.882	<.001	.001	3	2
LARGE_INTESTINE	CD300H →	+0.020	+3.000	<.001	.003	3	2
SOFT_TISSUE	PPDPFL →	+0.089	+4.222	<.001	.007	3	1
SOFT_TISSUE	C8orf74 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1
SOFT_TISSUE	LRIT2 →	+0.024	+5.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

OR2B2 by PCDHGA6 expression — SOFT_TISSUE

Explore this box plot interactively →