PCDHGA5

Across TCGA patient cohorts, PCDHGA5 mutation is significantly associated with the RNA expression of many other genes, with 5,281 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA5-associated genes across cancer lineages are EXOSC9, EIF5AL1, and KCTD9. Each is linked with PCDHGA5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA5-to-partner and partner-to-PCDHGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC9 grouped by PCDHGA5-low versus PCDHGA5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA5→partner) and Y-score (partner→PCDHGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	EXOSC9 →	+0.510	+2.601	<.001	.006	3	5
LUSC	EIF5AL1 →	+0.984	+2.339	<.001	.003	3	4
STAD	KCTD9 →	+0.583	+3.186	.001	.009	3	4
SKCM	SPRYD7 →	+0.377	+2.635	<.001	<.001	3	4
LUAD	PSMC3IP →	+0.472	+2.514	.004	.001	3	4
STAD	AIMP1 →	+0.396	+3.354	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,281 associations by consensus.

EXOSC9 by PCDHGA5 expression — STAD

Explore this box plot interactively →