PCDHGA5

Across TCGA patient cohorts, PCDHGA5 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA5-associated genes across cancer lineages are ASNS, FoxM1, and 4E-BP1. Each is linked with PCDHGA5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA5-to-partner and partner-to-PCDHGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PCDHGA5-low versus PCDHGA5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA5→partner) and Y-score (partner→PCDHGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.449	+1.807	.003	.024	3	5
LUSC	FoxM1 →	+0.282	+2.331	.028	.019	3	4
LUSC	4E-BP1 →	+0.621	+3.468	<.001	.002	1	5
UCEC	Annexin-1 →	+0.623	+2.459	<.001	<.001	3	3
SKCM	Smad4 →	+0.107	+1.662	.007	.011	3	3
SKCM	Src_pY527 →	-0.373	-1.807	.013	.024	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ASNS by PCDHGA5 expression — SKCM

Explore this box plot interactively →