PCDHGA5

Across TCGA cell cohorts, PCDHGA5 mutation is significantly associated with the RNA expression of many other genes, with 683 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA5-associated genes across cancer lineages are NUP88, OSCP1, and SGCB. Each is linked with PCDHGA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA5-to-partner and partner-to-PCDHGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP88 grouped by PCDHGA5-low versus PCDHGA5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA5→partner) and Y-score (partner→PCDHGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUP88 →	+0.554	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	OSCP1 →	+0.521	+1.949	.009	.002	3	2
LARGE_INTESTINE	SGCB →	+0.748	+1.949	.005	.002	3	2
LARGE_INTESTINE	MEAF6 →	+0.493	+2.652	<.001	.001	3	2
LARGE_INTESTINE	METAP1 →	+0.489	+3.321	.002	.002	3	2
LARGE_INTESTINE	FAM160A1 →	+0.707	+3.257	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 683 associations by consensus.

NUP88 by PCDHGA5 expression — LARGE_INTESTINE

Explore this box plot interactively →