PCDHGA4

Across TCGA patient cohorts, PCDHGA4 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA4-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with PCDHGA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGA4-to-partner and partner-to-PCDHGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PCDHGA4-low versus PCDHGA4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA4→partner) and Y-score (partner→PCDHGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.455	+2.321	.009	.032	3	4
COAD	Caspase-7-cleavedD198 →	+1.008	+2.584	<.001	.010	3	4
UCEC	4E-BP1 →	+0.288	+2.874	<.001	<.001	3	3
BRCA	eEF2 →	+0.408	+2.812	.002	.037	3	3
SKCM	eIF4E →	+0.189	+2.584	.002	.010	3	3
UCEC	14-3-3_beta →	-0.067	-1.365	.006	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

GAPDH by PCDHGA4 expression — COAD

Explore this box plot interactively →