PCDHGA3

Across TCGA patient cohorts, PCDHGA3 protein abundance is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCDHGA3-associated genes across cancer lineages are TSC22D1, PRUNE2, and SH3BGRL. Each is linked with PCDHGA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA3-to-partner and partner-to-PCDHGA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCDHGA3 versus TSC22D1 in GBM, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA3→partner) and Y-score (partner→PCDHGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TSC22D1 →	+0.952	+0.743	.004	.003	3	1
GBM	PRUNE2 →	+1.049	+0.743	.006	.003	3	1
GBM	SH3BGRL →	+1.179	+1.081	.001	.003	3	1
GBM	SEMA4F →	-0.648	-0.710	.002	.006	3	1
GBM	FGF2 →	+0.974	+0.743	.003	.003	3	1
GBM	RETREG3 →	-0.673	-0.953	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

PCDHGA3 vs TSC22D1 — GBM

Explore this scatter interactively →