PCDHGA3

Across TCGA patient cohorts, PCDHGA3 mutation is significantly associated with the RNA expression of many other genes, with 4,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA3-associated genes across cancer lineages are BOLA3, CD207, and THBD. Each is linked with PCDHGA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA3-to-partner and partner-to-PCDHGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BOLA3 grouped by PCDHGA3-low versus PCDHGA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA3→partner) and Y-score (partner→PCDHGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BOLA3 →	+0.234	+1.836	.007	.001	3	5
STAD	CD207 →	-0.663	-3.584	.006	.002	3	4
STAD	THBD →	-0.947	-3.584	.001	.002	3	4
STAD	NDUFA6 →	+0.542	+3.347	<.001	.004	3	4
LUSC	ENO2 →	+0.679	+2.099	.006	.003	3	4
UCEC	CMC2 →	+0.278	+1.364	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,330 associations by consensus.

BOLA3 by PCDHGA3 expression — UCEC

Explore this box plot interactively →