PCDHGA3

Across TCGA cell cohorts, PCDHGA3 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCDHGA3-associated genes across cancer lineages are MCHR2, ENPP4, and STMND1. Each is linked with PCDHGA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA3-to-partner and partner-to-PCDHGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by PCDHGA3-low versus PCDHGA3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA3→partner) and Y-score (partner→PCDHGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MCHR2 →	+0.018	+4.139	<.001	.001	3	2
LARGE_INTESTINE	ENPP4 →	+0.725	+3.459	.001	.001	3	2
LARGE_INTESTINE	STMND1 →	+0.304	+2.541	.001	.004	3	2
BLOOD_Leukemia	GCH1 →	+1.424	+3.199	.003	.007	3	2
BLOOD_Leukemia	TIFA →	+1.167	+3.199	.006	.007	3	2
BLOOD_Leukemia	MFN1 →	+0.882	+3.199	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

MCHR2 by PCDHGA3 expression — PANCREAS

Explore this box plot interactively →