PCDHGA2

Across TCGA patient cohorts, PCDHGA2 mutation is significantly associated with the RNA expression of many other genes, with 5,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA2-associated genes across cancer lineages are HSPA9, MTFP1, and SAC3D1. Each is linked with PCDHGA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA2-to-partner and partner-to-PCDHGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPA9 grouped by PCDHGA2-low versus PCDHGA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA2→partner) and Y-score (partner→PCDHGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA9 →	+0.423	+1.868	<.001	<.001	3	5
UCEC	MTFP1 →	+0.434	+2.402	<.001	<.001	3	4
UCEC	SAC3D1 →	+0.413	+2.343	<.001	<.001	3	4
LUSC	FXYD1 →	-0.326	-2.725	.004	.003	3	4
BLCA	UQCRHL →	+0.544	+3.212	.001	.009	3	4
UCEC	CCT5 →	+0.409	+1.993	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,466 associations by consensus.

HSPA9 by PCDHGA2 expression — UCEC

Explore this box plot interactively →