PCDHGA2

Across TCGA cell cohorts, PCDHGA2 mutation is significantly associated with the RNA expression of many other genes, with 505 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA2-associated genes across cancer lineages are PROP1, CA6, and PPIAL4G. Each is linked with PCDHGA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGA2-to-partner and partner-to-PCDHGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by PCDHGA2-low versus PCDHGA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA2→partner) and Y-score (partner→PCDHGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.017	+2.967	.001	.003	3	3
PANCREAS	CA6 →	+0.070	+4.011	<.001	.009	3	2
LUNG_SCLC	PPIAL4G →	+0.013	+3.954	.001	.009	3	2
LARGE_INTESTINE	CCDC134 →	+0.613	+3.301	.004	.003	3	2
LARGE_INTESTINE	UBE3A →	+0.517	+2.158	.001	.004	3	2
LARGE_INTESTINE	ZNF644 →	+0.373	+2.850	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 505 associations by consensus.

PROP1 by PCDHGA2 expression — BLOOD_Leukemia

Explore this box plot interactively →