PCDHGA12

Across TCGA patient cohorts, PCDHGA12 protein abundance is significantly associated with the RNA expression of many other genes, with 188 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCDHGA12-associated genes across cancer lineages are KLF1, ACVR1C, and TMEM175. Each is linked with PCDHGA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA12-to-partner and partner-to-PCDHGA12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCDHGA12 versus KLF1 in LSCC, with a Pearson correlation of -0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA12→partner) and Y-score (partner→PCDHGA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KLF1 →	-0.291	-0.753	.009	.008	3	1
LSCC	ACVR1C →	+0.755	+0.753	.006	.008	3	1
LSCC	TMEM175 →	+1.043	+1.000	.002	.007	3	1
LSCC	HSD17B3 →	+0.526	+1.126	.005	.005	3	1
LSCC	LIN28A →	+0.057	+0.753	.009	.008	3	1
LSCC	SLC44A5 →	+2.380	+0.753	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 188 associations by consensus.

PCDHGA12 vs KLF1 — LSCC

Explore this scatter interactively →