PCDHGA12

Across TCGA patient cohorts, PCDHGA12 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PCDHGA12-associated genes across cancer lineages are Rictor_pT1135, ATM, and Chk2_pT68. Each is linked with PCDHGA12 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGA12-to-partner and partner-to-PCDHGA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by PCDHGA12-low versus PCDHGA12-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA12→partner) and Y-score (partner→PCDHGA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rictor_pT1135 →	-0.215	-2.700	<.001	.004	3	3
UCEC	ATM →	-0.443	-1.834	<.001	.007	3	3
UCEC	Chk2_pT68 →	-0.147	-3.781	.005	<.001	3	3
STAD	Rictor →	-0.947	-3.443	.011	.004	3	2
STAD	eEF2 →	+0.341	+3.459	.002	.004	3	2
STAD	FoxM1 →	+0.347	+2.731	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Rictor_pT1135 by PCDHGA12 expression — STAD

Explore this box plot interactively →