Across TCGA pan-cancer cohorts, PCDHGA11 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PCDHGA11’s most consistent transcriptional readouts.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PCDHGA11 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PCDHGA11 is over-expressed in tumor.
CCRCC are the cancer types where PCDHGA11 tumor–normal differential expression is most reproducible.