PCDHGA11

Across TCGA patient cohorts, PCDHGA11 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA11-associated genes across cancer lineages are ASNS, 4E-BP1, and Cyclin-E2. Each is linked with PCDHGA11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGA11-to-partner and partner-to-PCDHGA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PCDHGA11-low versus PCDHGA11-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA11→partner) and Y-score (partner→PCDHGA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.683	+3.321	<.001	.010	3	3
UCEC	4E-BP1 →	+0.362	+3.169	<.001	<.001	3	3
COAD	Cyclin-E2 →	+0.257	+2.347	.006	.018	3	3
UCEC	FoxM1 →	+0.153	+1.378	.048	.008	3	3
UCEC	Ku80 →	+0.190	+1.391	.007	.005	3	3
UCEC	eEF2 →	+0.269	+2.115	.011	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ASNS by PCDHGA11 expression — STAD

Explore this box plot interactively →