Across TCGA patient cohorts, PCDHGA1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PCDHGA1-associated genes across cancer lineages are HER2, c-Kit, and p27_pT157. Each is linked with PCDHGA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGA1-to-partner and partner-to-PCDHGA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA1→partner) and Y-score (partner→PCDHGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2 →	+0.291	+2.415	<.001	.002	3	3
SKCM	c-Kit →	-0.485	-1.263	.015	.017	3	3
COAD	p27_pT157 →	+0.107	+1.593	.037	.022	3	3
COAD	PAI-1 →	+0.627	+2.008	.002	.005	3	3
UCEC	ATM →	-0.393	-2.074	.003	.004	3	3
SKCM	Paxillin →	+0.361	+2.807	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Exploration

PCDHGA1 survival (RNA) · tumor vs normal (RNA) · all PCDHGA1 data types