PCDHB9

Across TCGA patient cohorts, PCDHB9 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB9-associated genes across cancer lineages are MEK1, ATM, and Caspase-7-cleavedD198. Each is linked with PCDHB9 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB9-to-partner and partner-to-PCDHB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PCDHB9-low versus PCDHB9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB9→partner) and Y-score (partner→PCDHB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.382	+3.906	<.001	<.001	3	3
UCEC	ATM →	-0.470	-2.401	<.001	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.501	+1.947	.005	<.001	3	3
COAD	4E-BP1 →	+0.342	+3.008	.002	.019	3	3
LUAD	PKC-a_pS657 →	-0.291	-3.136	.015	.018	3	2
UCEC	Annexin_VII →	-0.087	-1.064	.039	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MEK1 by PCDHB9 expression — UCEC

Explore this box plot interactively →