PCDHB8

Across TCGA patient cohorts, PCDHB8 mutation is significantly associated with the RNA expression of many other genes, with 3,050 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB8-associated genes across cancer lineages are ABCC6, MZT1, and METTL5. Each is linked with PCDHB8 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHB8-to-partner and partner-to-PCDHB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCC6 grouped by PCDHB8-low versus PCDHB8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB8→partner) and Y-score (partner→PCDHB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ABCC6 →	-0.626	-2.651	.006	<.001	3	4
UCEC	MZT1 →	+0.614	+2.168	<.001	<.001	3	4
LUAD	METTL5 →	+0.319	+2.169	.002	.003	3	4
UCEC	TIMM50 →	+0.280	+2.736	.008	<.001	3	4
LUSC	MRPS15 →	+0.342	+2.184	.006	.009	2	5
UCEC	CENPU →	+0.611	+1.517	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,050 associations by consensus.

ABCC6 by PCDHB8 expression — LUAD

Explore this box plot interactively →