PCDHB8

Across TCGA patient cohorts, PCDHB8 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB8-associated genes across cancer lineages are NF2, PDCD4, and p38-MAPK_pT180_Y182. Each is linked with PCDHB8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB8-to-partner and partner-to-PCDHB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by PCDHB8-low versus PCDHB8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB8→partner) and Y-score (partner→PCDHB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NF2 →	+0.234	+2.321	.010	.005	3	3
UCEC	PDCD4 →	-0.519	-2.906	<.001	.001	3	3
STAD	p38-MAPK_pT180_Y182 →	-0.441	-2.321	.007	.034	2	3
STAD	Smad1 →	+0.141	+2.321	.029	.034	3	2
STAD	Src_pY416 →	-0.373	-3.459	.010	.005	3	2
STAD	c-Kit →	-0.322	-2.321	.024	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

NF2 by PCDHB8 expression — SKCM

Explore this box plot interactively →