PCDHB8

Across TCGA cell cohorts, PCDHB8 mutation is significantly associated with the RNA expression of many other genes, with 949 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB8-associated genes across cancer lineages are GRSF1, TXNL4A, and LORICRIN. Each is linked with PCDHB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHB8-to-partner and partner-to-PCDHB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRSF1 grouped by PCDHB8-low versus PCDHB8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB8→partner) and Y-score (partner→PCDHB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRSF1 →	+0.621	+2.541	<.001	.001	3	2
SKIN	TXNL4A →	+0.598	+3.451	.008	.002	3	2
LUNG_SCLC	LORICRIN →	+0.014	+2.425	.006	.005	3	2
LARGE_INTESTINE	CRLF3 →	+0.588	+3.459	<.001	.001	3	2
LARGE_INTESTINE	DTWD1 →	+0.731	+2.265	<.001	.001	3	2
LARGE_INTESTINE	IL27RA →	+0.831	+3.321	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 949 associations by consensus.

GRSF1 by PCDHB8 expression — LARGE_INTESTINE

Explore this box plot interactively →