PCDHB7

Across TCGA patient cohorts, PCDHB7 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB7-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and Syk. Each is linked with PCDHB7 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHB7-to-partner and partner-to-PCDHB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PCDHB7-low versus PCDHB7-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB7→partner) and Y-score (partner→PCDHB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.483	+2.906	.006	.001	2	5
COAD	Caspase-7-cleavedD198 →	+0.967	+2.008	<.001	.001	3	4
STAD	Syk →	+0.334	+2.115	.027	.016	3	3
COAD	C-Raf →	+0.150	+3.734	.001	<.001	3	3
UCEC	PCNA →	+0.141	+1.222	.020	.032	3	3
LUAD	XRCC1 →	+0.120	+1.700	.017	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Cyclin-B1 by PCDHB7 expression — STAD

Explore this box plot interactively →