PCDHB7

Across TCGA cell cohorts, PCDHB7 mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB7-associated genes across cancer lineages are CCDC163, KCNA6, and PPID. Each is linked with PCDHB7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB7-to-partner and partner-to-PCDHB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC163 grouped by PCDHB7-low versus PCDHB7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB7→partner) and Y-score (partner→PCDHB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC163 →	+0.511	+3.321	.001	.003	3	3
OESOPHAGUS	KCNA6 →	+0.036	+3.857	<.001	.002	3	2
LARGE_INTESTINE	PPID →	+0.528	+2.850	<.001	<.001	3	2
SKIN	HTR1B →	+0.413	+2.935	<.001	.002	3	2
LARGE_INTESTINE	MAPK8 →	+0.677	+3.321	<.001	.003	3	2
LARGE_INTESTINE	ACBD5 →	+0.771	+3.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

CCDC163 by PCDHB7 expression — LARGE_INTESTINE

Explore this box plot interactively →