PCDHB4

Across TCGA patient cohorts, PCDHB4 mutation is significantly associated with the RNA expression of many other genes, with 4,361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB4-associated genes across cancer lineages are PSMC3IP, LONP1, and TEPP. Each is linked with PCDHB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHB4-to-partner and partner-to-PCDHB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by PCDHB4-low versus PCDHB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB4→partner) and Y-score (partner→PCDHB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.524	+2.928	<.001	<.001	3	5
UCEC	LONP1 →	+0.483	+2.424	<.001	<.001	3	4
UCEC	TEPP →	-0.217	-1.874	.001	<.001	3	4
UCEC	L2HGDH →	+0.370	+1.890	.003	.001	2	5
UCEC	CCDC43 →	+0.456	+2.269	<.001	<.001	3	4
UCEC	CDCA2 →	+0.543	+1.485	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,361 associations by consensus.

PSMC3IP by PCDHB4 expression — UCEC

Explore this box plot interactively →