PCDHB4

Across TCGA patient cohorts, PCDHB4 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB4-associated genes across cancer lineages are FOXO3a_pS318_S321, FASN, and Caveolin-1. Each is linked with PCDHB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB4-to-partner and partner-to-PCDHB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PCDHB4-low versus PCDHB4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB4→partner) and Y-score (partner→PCDHB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOXO3a_pS318_S321 →	-0.111	-1.584	.005	.035	3	4
LUAD	FASN →	+0.476	+1.584	.004	.035	3	3
LUAD	Caveolin-1 →	-0.683	-2.000	.011	.009	3	3
SKCM	IRS1 →	+0.090	+1.339	.038	.037	3	3
UCEC	ATM →	-0.383	-1.687	.005	.040	3	3
STAD	Akt_pS473 →	-0.403	-2.984	.039	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FOXO3a_pS318_S321 by PCDHB4 expression — LUAD

Explore this box plot interactively →