PCDHB3

Across TCGA patient cohorts, PCDHB3 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB3-associated genes across cancer lineages are ATM, PDK1_pS241, and MYH11. Each is linked with PCDHB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB3-to-partner and partner-to-PCDHB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PCDHB3-low versus PCDHB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB3→partner) and Y-score (partner→PCDHB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.433	-1.299	<.001	.004	3	4
LUAD	PDK1_pS241 →	-0.170	-2.321	.010	.032	3	3
COAD	MYH11 →	-1.052	-2.000	.008	.027	3	3
COAD	Stathmin →	+0.124	+2.584	.008	.009	3	3
COAD	TAZ →	+0.145	+1.273	.016	.027	3	3
UCEC	PCNA →	+0.265	+1.628	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

ATM by PCDHB3 expression — UCEC

Explore this box plot interactively →